Toxicology and Pharmacology

Bhertha M. Tamura has completed her PhD at Clinical Hospital of the São Paulo’s Faculty of Medicine. Member of the American Academy of Dermatology, DASIL, IACD, Brazilian Society of Dermatology, Brazilian Society of Dermatologic Surgeons has published papers in reputed journals and has been serving as an editorial board member of repute besides being author of several book chapters and editor of cosmetic dermatology books.

Bhertha M. Tamura has completed her PhD at Clinical Hospital of the São Paulo’s Faculty of Medicine. Member of the American Academy of Dermatology, DASIL, IACD, Brazilian Society of Dermatology, Brazilian Society of Dermatologic Surgeons has published papers in reputed journals and has been serving as an editorial board member of repute besides being author of several book chapters and editor of cosmetic dermatology books.

POSITION TITLE: Research Professor, University of Iowa, Iowa City, IA; Emeritus Professor of Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable. Add/delete rows as necessary.)

The aim and focus of my research for many years has been to develop more effective and selective therapies for cancer patients based on data generated in preclinical models, and translated from bench to bed side and vice versa. In the 1990s, my laboratory, in collaboration with clinical colleagues at RPCI, developed the weekly schedule of 5-fluorouracil in combination with leucovorin as standard therapy for the treatment of colorectal cancer. In recent years, this laboratory was the first to demonstrate that therapeutic doses and schedule of methylselenocysteine, and seleno-L-methionine are potent inhibitors of hypoxia-induced and constitutively expressed HIF-1α and HIF-2α and associated specific types of miRNAs and VEGF expressed in tumor cells. Pronounced and sustained inhibition of these specific biomarkers was associated with therapeutic synergy with anticancer drugs. On the basis of data generated, a Phase 1 and 2 clinical trials of seleno-L- methionine in sequential combination with axitinib are under clinical evaluation in patients with advanced clear cell renal cell carcinoma.

Dr. Bayer’s research is mainly applied in nature. The major activity is centered around fabrication and characterization of functional polymer nanocomposites. The Smart Materials Platform@IIT has a number of research activities on fabrication and characterization of electrically and magnetically functional polymer nanocomposites, preparation and characterization of biomaterial nanocomposites for antimicrobial applications and drug delivery, processing of novel cellulosic materials, new generation polymer blends and surface modification and functionalization. Dr. Bayer participates in these research activities by supervising or helping supervise a number of graduate students and post doctoral colleagues. Moreover, Dr. Bayer has ongoing collaborations with the Department of Mechanical and Industrial Engineering at the University of Illinois at Chicago and with the Department of Mechanical and Aerospace Engineering at the University of Virginia.

Polymer Nanocomposites Surface Science Super-wetting and super-repellent surfaces Biopolymer Processing Smart Materials Emulsion Science and Technology

Experience about the X-ray crystallographic analyses, EM analeses, and NMR analyses of proteins, organic compounds, and inorganic compoundes for more than 15 years Enough experience of evaluation of molecular state of medicines using DSC or X-ray powder diffraction analysis Evaluation using the X-ray analyses of metal materials Deep knowledge about the higher mathematics, ability to apply it to financial engineering Management various programming languages Ability to develop of the application and operating system Pharmacist license

(1) Tertiary structure analyses of biomolecules using an X-ray crystallographic analysis, an electron microscope and the NMR (2) Development of the new dosage methods of pharmaceutical products (3) Properties of matter evaluation using various analysis techniques (for example, micro DSC, XRD, TEM etc.) of pharmaceutical products (4) Improvement based on the mechanical engineering of the preparation apparatus

Pall Thor Ingvarsson completed his PhD in the field of pharmaceutics from University of Copenhagen in 2013 and later on his postdoctoral studies in collaboration with Statens Serum Insititut, Copenhagen Denmark. He has an extensive experience in the field of spray drying large molecules in academia and industry and has post his academic career worked as a scientist at GlaxoSmithKline in the UK and Novo Nordisk in Denmark.

Pall Thor Ingvarsson completed his PhD in the field of pharmaceutics from University of Copenhagen in 2013 and later on his postdoctoral studies in collaboration with Statens Serum Insititut, Copenhagen Denmark. He has an extensive experience in the field of spray drying large molecules in academia and industry and has post his academic career worked as a scientist at GlaxoSmithKline in the UK and Novo Nordisk in Denmark.

Dr. Yan graduated in 2001 in Physical Chemistry from University of Science and Technology of China (USTC), and now is a full professor of USTC. His research focuses on carbon materials for energy conversion and storage, biomass conversion and green chemistry, and biomaterials and biomedicine based on polymers. Dr. Yan has published over 160 papers and edited three books.

Dr. Yan graduated in 2001 in Physical Chemistry from University of Science and Technology of China (USTC), and now is a full professor of USTC. His research focuses on carbon materials for energy conversion and storage, biomass conversion and green chemistry, and biomaterials and biomedicine based on polymers. Dr. Yan has published over 160 papers and edited three books.

Andrey Nikolaevych Belousov graduate from Kharkov Medical Institute in 1988. Doctor of Medicine degree on speciality - An¬esthesiology and Intensive Care since 2004. The title dissertation: “Extracorporal hemocorrection using magnet-controlled sorbent in intensive therapy of intoxication syndromes in patients with hepatopancreatoduodenales dis¬eases”. Author a new medecine products – nanotechnology preparations based on magnetite nanoparticles (Fe3O4) of the size 6-12 nm (www.nanolab.com.ua): the peroral form - Micromage-B (the biologically active additive officially registration in Ukraine); Magnet-controlled sorbent brand of MCS-B for extracorporal detoxication of biological liquids (officially registration in Ukraine and was allowed for medical practice); NanoBiocorrector for intravenous application – ICNB (intracorporal nanosorbent). A.N. Belousov is author new method of extracorporal hemocorrection using magnet-controlled sor¬bent (MCS-B). Author a new program for estimation degree the severity of the patient. Based on previously developed a universal analytical system of the physiological state of the body (PHUAS) by the author proposed a new automatic program objective assessment of the severity of the patient's condition. Overall, the program can improve health of the population in terms of underfunding by the rapid and objective examination of a large quantity of people. Early on, with the help of the developed program is made possible among surveyed identify risk groups in the severity of general condition, to determine the optimal and effective options for prevention and treatment, saving time and money for the survey, use the data to correlate them with various factors influence of the environment (ecology, nutrition, addictions, drug, vaccine, methods of intensive therapy, pharmacotherapy, etc.). The published more 180 scientific works on results application of nanotechnology preparation in experimental and practical medicine. He has got 7 patents for the invention, 21 collected scientific articles, 68 works in other publications and thesis of reports at international conferences and congresses, including 35 of them abroad (Rumania, Austria, Germany, Czech, Switzerland, Hungary, Denmark, Portugal, Italy, Canada, U.S.A., China, India, and others). Author of the scientific film which focuses on the elaboration of artificial liver device and the development of a new direction in medicine – Nanotechnology. Andrey Belousov was awarded Medical Diploma of Europe “An Honorary Scholar Europe” and R. Koch medal for the scientific achievements, development of a new direction in medicine and elaboration of new method of treatment by means preparations of nanotechnology in 2008. Member of the Ukrainian and Russian Society Nanotechnology. Assistant editor-in-chief of the journal Archives of Blood Transfusion & Disorders (ABTD). Crimson Publishers, LLC, New York, USA. Member of the Editorial Board Nanosensors and Nanomaterials Journal Oscine Group Pvt Ltd., Near Manyata Embassy, Bangalore-India. Member of the Editorial Board Journal of Anaesthesia and Preoperative Care. Delaware, USA. At now Andrey Belousov - the Head of Laboratory Applied Nanotechnologies in Ukraine, DM, Professor of Department Anesthesiology, Intensive Care, Transfusiology and Hematology Kharkov Medical Academy of Postgraduate Education.

Nanomedicine, Intensive Care, Transfusiology.

Dr. Jayateertha. R Diwan is currently working as Professor of Genetics and Plant Breeding at the University of Agricultural Sciences, Raichur, Karnataka, INDIA. He has completed his Master’s in Agriculture in Genetics and Plant Breeding from the University of Agricultural Sciences, Dharwad, INDIA. Dr Diwan received his Doctoral degree or PhD from University of Agricultural Sciences, Dharwad, Karnataka, INDIA. He worked in a project sponsored by Department For International Development (DFID). He worked as Scientist- Project Lead at the Barwale Foundation, Hyderabad.

Research interests include Molecular Breeding, Biofortification, Marker Assisted Selection with research on GABA, Glycemic Index, Fe and Zn content for better consumer acceptance. Contact Details: Dr. Jayateertha. R. Diwan

Maria de Lourdes Pereira is Associate Professor with Habilitation at the Department of Medical Sciences, University of Aveiro, and member of the Associate Laboratory CICECO-Aveiro Institute of Materials. She earned her Ph.D. in Biology (Animal Cytology) at the University of Aveiro working on the effects of some drugs on mice. Her teaching activities include essentially Cytology and Histology, and Cell Biology. She was Director of the Master on Molecular and Cell Biology (2008-2018) at University of Aveiro.

Research has been focused on the adverse effects of heavy metals, nanoparticles, and pesticides on animal models, especially male reproductive function, combining histological, cell biology and ultrastructural approaches. She co-authored several papers in international journals and book chapters on reputed publishers; she has been serving as an editorial board member of some journals, acting also as referee.

Prof. Bechan Sharma has completed his Ph.D from Banaras Hindu University-Varanasi and Central Drug Research Institute-Lucknow in 1988. He has been visiting scientist for about three years at University of Medicine and Dentistry of New Jersey-NJ Medical School, Newark, USA (2000-2002); and as a Visiting Professor at Italy, France, Thailand, Brazil, Germany and other countries. He is currently working as a senior Professor and Ex-Chairman of Departments of Biochemistry and Biotechnology at the University of Allahabad, a premier Central University of India.

Abstract Title: Inhibition of mammalian acetylcholinesterase by carbofuran and protection by vitamin C and Citrus limon fruit extract

Thomas Sanderson obtained his PhD at the age of 27 from the University of British Columbia, Vancouver, Canada and did postdoctoral studies at Michigan State University, USA. He is an associate professor at the INRS-Institut Armand-Frappier, Laval (Québec), Canada and has published more than 70 papers in reputed journals. His toxicology laboratory is focused on studying interactions of chemicals with steroidogenic enzymes in humans and wildlife and is currently funded by the Natural Sciences and Engineering Council (NSERC) of Canada and the Alternatives Research and Development Foundation (USA). Thomas is editorial board member of Toxicological Sciences and PeerJ.

Development and application of physiologically relevant in vitro models of human steroidogenesis in toxicology: the endocrine disrupting potential of neonicotinoid pesticides in humans